What is spermidine? FAQs about science, autophagy, fasting and spermidine.

Over time, the human body ages and loses youthfulness, vitality and health. This is mainly due to the loss of cellular functions and a slow but sure death of cells. As long as we are young, dead cellular components are replaced by new, young cellular components. However, as we age, our body loses this ability to regenerate itself.

Cells are damaged in a wide variety of everyday situations. One of the main reasons for cell damage is free radicals. These free radicals are created in the body mainly due to an unhealthy lifestyle.

However, our body cells have the ability to recognize free radical damage and neutralize it. In this process, the damaged parts of the cell are separated so that they cannot spread further. These parts of the cell are then considered "waste", which however can continue to accumulate over time, becoming a burden on the entire cell. This is one of the main reasons for aging.

The human body works like an expensive clock - very precise, but also sensitive. The state of health is influenced by both our lifestyle and our genes, and the aging process of our cells and body is accelerated by many factors in the process:

• Unbalanced diet: highly processed foods with a high content of saturated fats and sugars provide a lot of energy to the body, but the energy offered is of low quality for our cells. This leads to unnecessary damage in our cells and organs, which over time can lead to accelerated aging and disease.
• A lack of exercise: Too little exercise and the increasingly sedentary part of our lifestyle reduce and change the metabolism in our body towards energy storage instead of energy burning.
• Persistent, high stress levels (at home and at work): Too high a level of stress over too long a period of time leads to overuse of our organs and immune system. This reduces the ability of our body to eliminate the cellular damage accumulated over time and prevent new damage.
• Sleep deprivation: If the body is deprived of the opportunity to process the daily stress at night due to lack of good sleep, this leads to an overload of the overall system, the resistance to stress decreases and the entire body is weakened.
• Excessive cigarette and alcohol consumption: high levels of free radicals from cigarette and alcohol consumption damage our cells from the inside out.
• Irregular or no fasting intervals: no or too irregular fasting periods reduce the autophagy process in our cells, which leads to the fact that damaged cell components are not sufficiently eliminated and cells are thus not comprehensively renewed.

Sufficient physical exercise, a balanced diet and good sleep are frequently regarded as factors for good health. Regular fasting, on the other hand, is rarely mentioned as a major factor in sustained good health. Fasting does require a marked degree of discipline, but the fact is that fasting, through autophagy activation, leads to many benefits for those who have the discipline necessary for regular and sufficiently long periods of fasting.

Fasting is the total or partial abstention from all or certain foods for a specified period of time. It is the most natural and effective way to activate the body's recycling mechanism, which is called autophagy. The lack of energy due to reduced food intake causes our cells to turn to alternative energy resources, namely damaged cellular components. These damaged cellular components are then broken down and new energy is produced. Any kind of reduction or avoidance of calories, for example by fasting for a day or longer, activates the autophagy process.

The body's own process of autophagy (ancient Greek for "self - (auto) eating (phagein)") is a kind of recycling process of the cells, in which the cells break down damaged or unusable cell components and generate energy from them.
Damaged cellular components contribute significantly to the development of age-related diseases. By recycling the old cellular components, cellular metabolism is promoted and the cell is kept young and healthy. Functioning autophagy is therefore essential for protection against disease.
Autophagy in the cell can be stimulated by fasting, exercise and certain substances. In view of this medical relevance, the Japanese Yoshinori Ohsumi was awarded the Nobel Prize in Medicine in 2016 for advances in the elucidation of autophagy.

The best way to activate autophagy is fasting. However, this requires a high degree of discipline, as it is usually difficult to integrate fasting as a fixed part of our daily routine. Social interactions, professional obligations and a varied leisure and family life present us with great challenges in this context. The solution to these challenges lies in different natural substances that enable the activation of autophagy without actually having to strictly fast.

Spermidine (a so-called polyamine) is a natural component of our cells, which is produced by our body. Spermidine can also be found in varying concentrations in a wide variety of fruits, vegetables, in meat and also cheese. About one third of the spermidine content in our body is produced by the body's own cells, the rest is ingested through food and produced by the bacteria in our digestive tract. A balanced diet can therefore help to keep the spermidine content in our body at a high level.

Spermidine is a natural substance that can be found everywhere in nature. As a polyamine, spermidine is a very small molecule that can be easily absorbed due to its size. Spermidine is found especially in male seminal fluid, which is why the name was derived from it.

Spermidine can be found in varying concentrations in fruits, vegetables, meats, cheeses, and in each of our body's cells, however, the body's production of spermidine in our cells decreases over time. Therefore, it is essential to pay attention to daily spermidine intake. Although this aspect has only been discovered in recent years, hundreds of scientists around the world are currently engaged in spermidine research in the laboratory. With spermidineLIFE^® we, as Longevity Labs+, bring the results of this scientific research to your home.

Currently, there are no known side effects from ingesting spermidine. This is because spermidine is not only absorbed through daily food, but our body itself produces spermidine.

spermidineLIFE^® Original 365+ contains natural spermidine from wheat germ extract with high spermidine content as well as zinc and vitamin B1. For a more detailed breakdown of ingredients, you can consult our product page. Due to the novelty and uniqueness of our product, spermidineLIFE^® has been approved by EFSA (European Food Safety Authority) as a "Novel Food".

The spermidine in spermidineLIFE^® is of 100% natural origin and is extracted from wheat germ using very complex processes. The extraction is water-based

It is best to take two capsules once a day with a meal - whether this is in the morning, at noon or in the evening is up to your personal preference, but we recommend taking them at regular, consistent times of the day.

Since our product spermidineLIFE^® Original 365+ is a food supplement and the legal restrictions regarding statements about the effects of food supplements are very strict, we are not allowed to make comprehensive statements in this context. We ask for your understanding that we only refer to relevant literature and specialist publications here. If you have any further questions, please contact your physicians.

spermidineLIFE^® Original 365+ contains a new type of wheat germ extract, which differs significantly from other spermidine products on the market (in liquid and dry form) due to the focus on spermidine enrichment in the newly developed extraction process. The special process for spermidine enrichment was developed in years of cooperation between researchers from the University of Graz and experts from our company. This special extraction process has made the targeted enrichment of spermidine in the extract possible in the first place. For the approval of the resulting products, such as spermidineLIFE^®, the "Novel-Food Approval" of the AGES (Austrian Agency for Health and Food Safety) and the EFSA (European Food Safety Authority) was applied for and approved. It should be noted that we attach great importance to the highest quality standards, which is why the wheat germ extract is produced in our own production in Austria.

spermidineLIFE^® Original 365+ is a food supplement and serves to supplement the normal diet. Therefore, there are no time restrictions on taking it.

Lactose: spermidineLIFE^® Original 365+ is lactose-free.
Fructose: spermidineLIFE^® Original 365+ has no added sugar or sugar alcohol.
Gluten: Because the spermidine is derived from wheat germ, spermidineLIFE^® Original 365+ contains gluten.

When we entered the market with our original product spermidineLIFE^® in 2019, we did not realize how successful we would be. In order to meet the high demand for our innovative everyday solutions, after further research and based on scientific findings, we launched additional products under the spermidineLIFE^® brand range. Nevertheless, in order to best communicate to our customers which of our products is most suitable for them, the addition spermidineLIFE^® Original 365+ has been added for our original product. Original because we were the first and for a long time the only ones on the market in 2019, and 365+ to clarify that this product is designed for daily use and should be taken at any time of year, in any situation in life. It should be noted that the ingredients and quality standards and everything else that makes us unique as a brand spermidineLIFE^® remain the same!

spermidineLIFE^® Immunity+ contains natural spermidine from wheat germ extract with high spermidine content as well as shiitake powder, vitamin B1, vitamin C and zinc. For a more detailed breakdown of ingredients, you can consult our product page.

spermidineLIFE^® Immunity+ can be taken permanently. Especially at times of increased immune stress, a dose of 4 capsules per day is recommended.

Depending on your needs, you can either take 2 capsules twice a day or 4 capsules once a day. In any case, we recommend taking the capsules in the course of a meal to increase bioavailability.

spermidineLIFE^® Immunity+ contains, in addition to spermidine from wheat germ extract and vitamin B1, an increased dose of zinc, as well as the ingredients shiitake mushroom powder and vitamin C, which together with spermidine form a perfect combination to support the immune cells.

It is possible to take spermidineLIFE^® Original 365+ and spermidineLIFE^® Immunity+ at the same time. The two products are a great combination, especially in the case of increased immune stress, such as in winter.

spermidineLIFE^® Immunity+ contains in addition to spermidine also shiitake powder, vitamin C and an increased amount of zinc to optimally support the immune cells.

spermidineLIFE^® Immunity+ stands out due to the ingredient spermidine. The combination with shiitake powder, vitamin C and the increased dose of zinc results in a unique composition to support immune cells.⁴

Lactose: spermidineLIFE^® Immunity+ is lactose-free.
Fructose: spermidineLIFE^® Immunity+ has no added sugar or sugar alcohol.
Gluten: Because the spermidine is derived from wheat germ, spermidineLIFE^® Immunity+ contains gluten.

spermidineLIFE^® Memory+ contains 100% natural spermidine from wheat germ extract with high spermidine content, as well as Brahmi powder, saffron extract, zinc, iron and vitamin B1. For a more detailed breakdown of ingredients, you can consult our product page.

spermidineLIFE^® Memory+ can be taken permanently. Standard daily dose is 2 capsules, in case of tiredness and fatigue it is recommended to take 4 capsules per day.

Depending on your needs, you can either take 2 capsules twice a day or 4 capsules once a day. In any case, we recommend taking the capsules in the course of a meal to increase the bioavailability.

spermidineLIFE^® Memory+ contains in addition to spermidine from 100% natural wheat germ extract and vitamin B1 an increased dose of zinc, as well as the ingredients Brahmi powder, saffron and iron, which in combination are a perfect combination to support the brain cells.

It is possible to take spermidineLIFE^® Memory+ simultaneously with other spermidineLIFE^® products. Especially in case of exhaustion and fatigue, as well as increased immune load or in winter, a combination of several spermidineLIFE^® products is a great supplement.

spermidineLIFE^® Memory+ renews cells with the proven formula of spermidineLIFE^® Original 365+. The additional ingredients iron, saffron & brahmi also support normal cognitive function.

spermidineLIFE^® Memory+ stands out due to the ingredient spermidine. The combination with Brahmi powder, saffron extract, iron and the increased dose of zinc gives a unique composition to support brain cells.

Vegan: spermidineLIFE^® Memory+ is vegan. Lactose: spermidineLIFE^® Memory+ is lactose-free. Fructose: spermidineLIFE^® Memory+ has no added sugar or sugar alcohol. Gluten: Because the spermidine is derived from wheat germ, spermidineLIFE^® Memory+ contains gluten.

spermidineLIFE^® Pro+ contains natural spermidine from wheat germ extract with high spermidine content, as well as zinc and vitamin B1. For a more detailed breakdown of ingredients, you can consult our product page.

In addition to the longer intake of our spermidineLIFE^® Original 365+, a more intensive support of cell renewal 2 times a year in a 10:2 rythm using spermidineLIFE^® Pro+ is the optimal supplement. The intensive extra boost through spermidineLIFE^® Pro+ is ideally suited as a replacement or combination for the fasting period.

Yes, it is possible to divide the daily dose as shown in the example.

We recommend to continue taking the next day as usual and to extend the course of treatment by one day, as a daily dose of up to 6 mg has been classified as safe by the EFSA.

Due to the daily dose of 6mg, spermidineLIFE^® Pro+ should not be taken simultaneously with other spermidineLIFE^® products. In addition to the longer intake of our spermidineLIFE^® Original 365+, a more intensive support of cell renewal 2 times a year in a 10:2 rythm using spermidineLIFE^® Pro+ is the optimal supplement.

Since we take customer feedback to heart and have often been made aware that especially for frail people taking in capsule form is problematic, we have decided for our product spermidineLIFE^® Pro+ for this type of intake.

In general, it is up to you whether you prefer to drink the beverage cold or warm. The only important thing is that the water temperature does not exceed 60°C, as spermidine can decompose at higher temperatures and is no longer usable for the body.

spermidineLIFE^® Pro+ is suitable for anyone who wants to do something good for his body with an intensive cure for cell renewal, without necessarily having a fasting period. The cure is also ideal to support the regular cell renewal of spermidineLIFE^® Original 365+ 2x a year with a higher dose and thus achieve the optimal effects of the products.

Vegan: spermidineLIFE^® Pro+ is vegan. Lactose: spermidineLIFE^® Pro+ is lactose-free. Fructose: spermidineLIFE^® Pro+ has no added sugar or sugar alcohol. Gluten: Because the spermidine is derived from wheat germ, spermidineLIFE^® Pro+ contains gluten.

Since the safety of our customers is our top priority, we have registered our spermidine-rich wheat germ extract as a Novel Food with the European Food Safety Authority. A daily dose of up to 6 mg of spermidine was classified as safe and harmless. Because of this, we have decided on this high dosage, so that the cell renewal can be intensively supported in optimal quality and compatibility 2x a year.

NAD stands for nicotinamide adenine dinucleotide, an important coenzyme form in the body that plays a crucial role in energy metabolism.

The idea behind supplementing with NAD precursors (NAM, NMN, etc.) is to increase NAD levels in the body, as NAD is a coenzyme involved in many metabolic processes related to energy production and cellular functions.

1. nadLIFE^® Energy+ contains a combination of NAM and ribose.
2. NAM passes directly through the cell membrane and does not need to be transformed.
3. In the cell, NAM accumulates with the ribose present in the product and the phosphorus found in the cell.
4. It can then be further processed to NAD+ and support the energy balance in our cells.

With spermidineLIFE^® the focus is on renewing the cells¹, while nadLIFE^® supports the energy balance in our cells to get through everyday life even better.⁶

nadLIFE^® Energy+ contains the innovative combination of niacin (as nicotinamide), spermidine and zinc.

Niacin and nicotinamide are chemically related compounds, but they are not exactly the same. Both are forms of vitamin B3 (also known as niacin) that play an important role in the human body.
Niacin is a collective term for several related compounds, including nicotinic acid (also known as nicotinic acid) and nicotinamide (also known as niacinamide).

Is there a connection between nicotinamide and nicotine?
Although nicotinamide and nicotine are similar in terms of their chemical structure, they have very different biological effects and impacts on the human body. Nicotinamide is a vitamin, while nicotine is a harmful psychoactive substance.

The product is based on patents for mitochondrial respiration and the synergistic action of niacin with ribose and nicain with spermidine.

No, however the indicated daily intake of one stick per day should not be exceeded.

nadLIFE^® Energy+ may be supplemented from the age of 18.

Yes, because the two energy suppliers work on different levels. nadLIFE^® Energy+ works on a cellular level and coffee or energy drinks work on neurotransmitters via the brain.

Yes! The products have been developed so that they can be combined without any problems.

Dissolve one sachet daily in water and enjoy with a meal. One package contains a monthly ration of 30 sachets.
Again, continuity is the key to success!

nadLIFE^® Energy+ should be taken with a meal, as it can interrupt fasting due to the ribose it contains.

nadLIFE^® Energy+ contains 160 mg of niacin - a very high amount of niacin allowed by regulatory guidelines. The higher dosage is necessary to provide more energy to your cells.¹ ⁶ Lower doses of niacin would not be sufficient to produce a noticeable effect. However, it is important not to exceed the recommended daily dose of one sachet of nadLIFE^® Energy+.