What is spermidine?

Cells are the smallest functional units of our body – you can think of them as tiny “building blocks of life.” Each of our approximately 30 trillion cells has specific tasks: muscle cells enable movement, nerve cells transmit signals, and immune cells protect us.

Within the cells are specialized structures such as mitochondria, often referred to as the "powerhouses of the cell" because they produce energy (ATP). For these complex processes to function properly, cells must regularly break down and recycle damaged components – a process known as autophagy.

This is where spermidine comes into play: this natural molecule is scientifically associated with supporting autophagy. Early studies suggest that spermidine may help promote the cell’s internal cleaning and renewal mechanisms – a promising approach, particularly in the context of healthy aging and cellular vitality.

Our cells are exposed to daily stressors – such as psychological stress, environmental influences, and the natural aging process. To protect them, a healthy lifestyle is essential: a balanced diet, regular exercise, sufficient sleep, and mindful stress management.

Certain nutrients can also specifically support cellular function. Spermidine is one such compound – naturally produced by our bodies and associated with the activation of cellular self-cleaning processes (autophagy). This “inner cell maintenance” helps keep cells functional and healthy for longer.

Mitochondria are often called the “powerhouses of our cells” – and rightly so: they produce most of the energy (ATP) our body needs for movement, brain function, cellular repair, and much more.

As we age, mitochondrial performance tends to decline. Studies show that processes like autophagy help keep mitochondria functioning properly. Spermidine is linked in research to the promotion of these cellular cleaning processes – potentially helping to maintain healthy, energy-efficient cells.

Spermidine (a type of polyamine) is a naturally occurring compound found in our cells and produced by the body. It is also present in varying concentrations in many fruits, vegetables, meats, and cheeses. About one-third of the spermidine in our body is synthesized by our own cells, while the rest comes from dietary intake and the bacteria in our digestive tract. A balanced diet can therefore help maintain optimal spermidine levels in the body.

Spermidine naturally occurs in many foods – especially in plant-based sources. The foods richest in spermidine include:

• Wheat germ
• Aged cheese
• Soybeans
• Mushrooms
• Legumes
• Broccoli and leafy greens

However, the spermidine content in food can vary greatly depending on the type, origin, and processing. Those who want to ensure a consistent daily intake often turn to standardized dietary supplements like spermidineLIFE^®, which is made from high-quality wheat germ extract.

There is no officially defined daily requirement for spermidine, as it is not classified as an essential nutrient like vitamin C. However, studies suggest that regular intake – through spermidine-rich foods or supplementation – can be beneficial for supporting cellular processes such as autophagy.

One capsule of spermidineLIFE^® Original 365+ contains 1 mg of natural spermidine per daily serving – roughly equivalent to the amount found in several tablespoons of wheat germ. This dosage is based on scientific research and is continuously evaluated in collaboration with leading universities.

As with any supplement, consistency is key. Daily use over a longer period is recommended. If you have health concerns or preexisting conditions, please consult a healthcare professional before use.

Fasting activates a natural protective mechanism in the body: cells begin breaking down and recycling damaged components – a process known as autophagy. This self-cleaning mechanism is crucial for cellular renewal and maintenance.

However, fasting also places stress on the body: metabolic processes slow down, and not everyone tolerates extended periods without food – especially under physical or mental strain.

Interestingly, scientific studies show that spermidine can trigger similar cellular processes as fasting – particularly autophagy. This means that the positive effects of fasting may potentially be supported without actually giving up food. spermidineLIFE^® provides this molecule in a standardized form – ideal for those looking to promote cellular health without the challenges of fasting.

Autophagy (from the Greek "auto" = self and "phagein" = to eat) is the body’s natural process of breaking down and recycling damaged or unnecessary cellular components – essentially a biological recycling system. The energy released is used for vital cell functions, while potentially harmful waste is eliminated, reducing the risk of disease.

Proper autophagy helps keep our cells youthful and functional – playing an essential role in protecting against age-related illnesses. In 2016, Japanese cell biologist Yoshinori Ohsumi received the Nobel Prize in Medicine for his groundbreaking research on autophagy.

Autophagy can be activated through fasting, physical activity, or specific bioactive compounds. And here, spermidine is key: without it, autophagy cannot function effectively. While the body produces spermidine naturally, levels decrease significantly with age. Studies show that spermidine can trigger many of the same cellular benefits as fasting – but without the need to restrict calories or undergo stress.

Over time, the human body ages and gradually loses its youthfulness, vitality, and health. This is primarily due to a decline in cellular function and the slow but steady death of cells. While we are young, damaged or dead cell components are efficiently replaced by new, healthy ones. As we age, however, the body’s ability to regenerate itself decreases significantly.

spermidineLIFE^® is an innovative dietary supplement that contains natural spermidine extracted from high-quality wheat germ. It was developed in collaboration with international research partners and is the first product worldwide whose active ingredient, CelVio Complex^®, has been studied in clinical trials in connection with cellular health.

Spermidine is a naturally occurring compound in the human body and is associated with the activation of autophagy – the cell’s internal recycling and renewal process. As we age, our body’s natural spermidine levels decline significantly. spermidineLIFE^® offers a standardized, scientifically grounded way to replenish spermidine daily – supporting healthy cell function and active cellular metabolism.

The CelVio Complex^® is the core component of spermidineLIFE^® and nadLIFE^® products by Longevity Labs+. It is a special extract made from wheat germ that contains 100% natural spermidine. This spermidine is obtained through a gentle extraction process developed in cooperation with the University of Graz to ensure that the ingredients are preserved as naturally as possible.

We are committed to pure nature – from start to finish. The wheat germ is processed completely untreated and without the addition of synthetic spermidine. By using only water as a solvent, we stay true to our principle of naturalness at every step of production.

Our mission is to support people in aging healthily – grounded in the understanding that true well-being starts at the cellular level. We are guided by science and committed to supporting the body’s natural processes in a targeted and effective way.

At Longevity Labs+, we see it as our responsibility to advance the scientific understanding of spermidine while creating products that meet the highest quality standards. spermidineLIFE^® is designed not only to support daily well-being but also to serve as a foundation for future human studies.

We believe that the more we understand how aging works, the better we can live: longer, healthier, and more actively.

spermidineLIFE^® Original 365+ contains natural spermidine from wheat germ extract with high spermidine content as well as zinc and vitamin B1. For a more detailed breakdown of ingredients, you can consult our product page. Due to the novelty and uniqueness of our product, spermidineLIFE^® has been approved by EFSA (European Food Safety Authority) as a "Novel Food".

The spermidine in spermidineLIFE^® is of 100% natural origin and is extracted from wheat germ using very complex processes. The extraction is water-based

It is best to take two capsules once a day with a meal - whether this is in the morning, at noon or in the evening is up to your personal preference, but we recommend taking them at regular, consistent times of the day.

Since our product spermidineLIFE^® Original 365+ is a food supplement and the legal restrictions regarding statements about the effects of food supplements are very strict, we are not allowed to make comprehensive statements in this context. We ask for your understanding that we only refer to relevant literature and specialist publications here. If you have any further questions, please contact your physicians.

spermidineLIFE^® Original 365+ contains a new type of wheat germ extract, which differs significantly from other spermidine products on the market (in liquid and dry form) due to the focus on spermidine enrichment in the newly developed extraction process. The special process for spermidine enrichment was developed in years of cooperation between researchers from the University of Graz and experts from our company. This special extraction process has made the targeted enrichment of spermidine in the extract possible in the first place. For the approval of the resulting products, such as spermidineLIFE^®, the "Novel-Food Approval" of the AGES (Austrian Agency for Health and Food Safety) and the EFSA (European Food Safety Authority) was applied for and approved. It should be noted that we attach great importance to the highest quality standards, which is why the wheat germ extract is produced in our own production in Austria.

spermidineLIFE^® Original 365+ is a food supplement and serves to supplement the normal diet. Therefore, there are no time restrictions on taking it.

Lactose: spermidineLIFE^® Original 365+ is lactose-free.
Fructose: spermidineLIFE^® Original 365+ has no added sugar or sugar alcohol.
Gluten: Because the spermidine is derived from wheat germ, spermidineLIFE^® Original 365+ contains gluten.

When we entered the market with our original product spermidineLIFE^® in 2019, we did not realize how successful we would be. In order to meet the high demand for our innovative everyday solutions, after further research and based on scientific findings, we launched additional products under the spermidineLIFE^® brand range. Nevertheless, in order to best communicate to our customers which of our products is most suitable for them, the addition spermidineLIFE^® Original 365+ has been added for our original product. Original because we were the first and for a long time the only ones on the market in 2019, and 365+ to clarify that this product is designed for daily use and should be taken at any time of year, in any situation in life. It should be noted that the ingredients and quality standards and everything else that makes us unique as a brand spermidineLIFE^® remain the same!

spermidineLIFE^® Immunity+ contains natural spermidine from wheat germ extract with high spermidine content as well as shiitake powder, vitamin B1, vitamin C and zinc. For a more detailed breakdown of ingredients, you can consult our product page.

spermidineLIFE^® Immunity+ can be taken permanently. Especially at times of increased immune stress, a dose of 4 capsules per day is recommended.

Depending on your needs, you can either take 2 capsules twice a day or 4 capsules once a day. In any case, we recommend taking the capsules in the course of a meal to increase bioavailability.

spermidineLIFE^® Immunity+ contains, in addition to spermidine from wheat germ extract and vitamin B1, an increased dose of zinc, as well as the ingredients shiitake mushroom powder and vitamin C, which together with spermidine form a perfect combination to support the immune cells.

It is possible to take spermidineLIFE^® Original 365+ and spermidineLIFE^® Immunity+ at the same time. The two products are a great combination, especially in the case of increased immune stress, such as in winter.

spermidineLIFE^® Immunity+ contains in addition to spermidine also shiitake powder, vitamin C and an increased amount of zinc to optimally support the immune cells.

spermidineLIFE^® Immunity+ stands out due to the ingredient spermidine. The combination with shiitake powder, vitamin C and the increased dose of zinc results in a unique composition to support immune cells.⁴

Lactose: spermidineLIFE^® Immunity+ is lactose-free.
Fructose: spermidineLIFE^® Immunity+ has no added sugar or sugar alcohol.
Gluten: Because the spermidine is derived from wheat germ, spermidineLIFE^® Immunity+ contains gluten.

spermidineLIFE^® Memory+ contains 100% natural spermidine from wheat germ extract with high spermidine content, as well as Brahmi powder, saffron extract, zinc, iron and vitamin B1. For a more detailed breakdown of ingredients, you can consult our product page.

spermidineLIFE^® Memory+ can be taken permanently. Standard daily dose is 2 capsules, in case of tiredness and fatigue it is recommended to take 4 capsules per day.

Depending on your needs, you can either take 2 capsules twice a day or 4 capsules once a day. In any case, we recommend taking the capsules in the course of a meal to increase the bioavailability.

spermidineLIFE^® Memory+ contains in addition to spermidine from 100% natural wheat germ extract and vitamin B1 an increased dose of zinc, as well as the ingredients Brahmi powder, saffron and iron, which in combination are a perfect combination to support the brain cells.

It is possible to take spermidineLIFE^® Memory+ simultaneously with other spermidineLIFE^® products. Especially in case of exhaustion and fatigue, as well as increased immune load or in winter, a combination of several spermidineLIFE^® products is a great supplement.

spermidineLIFE^® Memory+ renews cells with the proven formula of spermidineLIFE^® Original 365+. The additional ingredients iron, saffron & brahmi also support normal cognitive function.

spermidineLIFE^® Memory+ stands out due to the ingredient spermidine. The combination with Brahmi powder, saffron extract, iron and the increased dose of zinc gives a unique composition to support brain cells.

Vegan: spermidineLIFE^® Memory+ is vegan. Lactose: spermidineLIFE^® Memory+ is lactose-free. Fructose: spermidineLIFE^® Memory+ has no added sugar or sugar alcohol. Gluten: Because the spermidine is derived from wheat germ, spermidineLIFE^® Memory+ contains gluten.

spermidineLIFE^® Pro+ contains natural spermidine from wheat germ extract with high spermidine content, as well as zinc and vitamin B1. For a more detailed breakdown of ingredients, you can consult our product page.

In addition to the longer intake of our spermidineLIFE^® Original 365+, a more intensive support of cell renewal 2 times a year in a 10:2 rythm using spermidineLIFE^® Pro+ is the optimal supplement. The intensive extra boost through spermidineLIFE^® Pro+ is ideally suited as a replacement or combination for the fasting period.

Yes, it is possible to divide the daily dose as shown in the example.

We recommend to continue taking the next day as usual and to extend the course of treatment by one day, as a daily dose of up to 6 mg has been classified as safe by the EFSA.

Due to the daily dose of 6mg, spermidineLIFE^® Pro+ should not be taken simultaneously with other spermidineLIFE^® products. In addition to the longer intake of our spermidineLIFE^® Original 365+, a more intensive support of cell renewal 2 times a year in a 10:2 rythm using spermidineLIFE^® Pro+ is the optimal supplement.

Since we take customer feedback to heart and have often been made aware that especially for frail people taking in capsule form is problematic, we have decided for our product spermidineLIFE^® Pro+ for this type of intake.

In general, it is up to you whether you prefer to drink the beverage cold or warm. The only important thing is that the water temperature does not exceed 60°C, as spermidine can decompose at higher temperatures and is no longer usable for the body.

spermidineLIFE^® Pro+ is suitable for anyone who wants to do something good for his body with an intensive cure for cell renewal, without necessarily having a fasting period. The cure is also ideal to support the regular cell renewal of spermidineLIFE^® Original 365+ 2x a year with a higher dose and thus achieve the optimal effects of the products.

Vegan: spermidineLIFE^® Pro+ is vegan. Lactose: spermidineLIFE^® Pro+ is lactose-free. Fructose: spermidineLIFE^® Pro+ has no added sugar or sugar alcohol. Gluten: Because the spermidine is derived from wheat germ, spermidineLIFE^® Pro+ contains gluten.

Since the safety of our customers is our top priority, we have registered our spermidine-rich wheat germ extract as a Novel Food with the European Food Safety Authority. A daily dose of up to 6 mg of spermidine was classified as safe and harmless. Because of this, we have decided on this high dosage, so that the cell renewal can be intensively supported in optimal quality and compatibility 2x a year.

NAD stands for nicotinamide adenine dinucleotide, an important coenzyme form in the body that plays a crucial role in energy metabolism.

The idea behind supplementing with NAD precursors (NAM, NMN, etc.) is to increase NAD levels in the body, as NAD is a coenzyme involved in many metabolic processes related to energy production and cellular functions.

1. nadLIFE^® Energy+ contains a combination of NAM and ribose.
2. NAM passes directly through the cell membrane and does not need to be transformed.
3. In the cell, NAM accumulates with the ribose present in the product and the phosphorus found in the cell.
4. It can then be further processed to NAD+ and support the energy balance in our cells.

With spermidineLIFE^® the focus is on renewing the cells¹, while nadLIFE^® supports the energy balance in our cells to get through everyday life even better.⁶

nadLIFE^® Energy+ contains the innovative combination of niacin (as nicotinamide), spermidine and zinc.

Niacin and nicotinamide are chemically related compounds, but they are not exactly the same. Both are forms of vitamin B3 (also known as niacin) that play an important role in the human body.
Niacin is a collective term for several related compounds, including nicotinic acid (also known as nicotinic acid) and nicotinamide (also known as niacinamide).

Is there a connection between nicotinamide and nicotine?
Although nicotinamide and nicotine are similar in terms of their chemical structure, they have very different biological effects and impacts on the human body. Nicotinamide is a vitamin, while nicotine is a harmful psychoactive substance.

The product is based on patents for mitochondrial respiration and the synergistic action of niacin with ribose and nicain with spermidine.

No, however the indicated daily intake of one stick per day should not be exceeded.

nadLIFE^® Energy+ may be supplemented from the age of 18.

Yes, because the two energy suppliers work on different levels. nadLIFE^® Energy+ works on a cellular level and coffee or energy drinks work on neurotransmitters via the brain.

Yes! The products have been developed so that they can be combined without any problems.

Dissolve one sachet daily in water and enjoy with a meal. One package contains a monthly ration of 30 sachets.
Again, continuity is the key to success!

nadLIFE^® Energy+ should be taken with a meal, as it can interrupt fasting due to the ribose it contains.

nadLIFE^® Energy+ contains 160 mg of niacin - a very high amount of niacin allowed by regulatory guidelines. The higher dosage is necessary to provide more energy to your cells.¹ ⁶ Lower doses of niacin would not be sufficient to produce a noticeable effect. However, it is important not to exceed the recommended daily dose of one sachet of nadLIFE^® Energy+.